Thyroid Cancer

Thyroid cancer is the most common type of endocrine cancer. Although a diagnosis of cancer is always concerning, the vast majority of thyroid cancers are very treatable and are associated with an excellent prognosis.

There are four main types of cancer of the thyroid:

• Papillary thyroid cancer is the most common, comprising about 80% of all thyroid cancers. It tends to grow slowly but may spread to lymph nodes in the neck or elsewhere in the body. With early intervention, however, papillary thyroid cancer generally has an excellent prognosis.

• Follicular thyroid cancers represent about 15% of all thyroid cancers. Follicular thyroid cancers usually do not spread to the lymph nodes, however, in some cases they can spread to other parts of the body, such as the lungs or bones.

• Medullary thyroid cancer (MTC) represents about 3% of all thyroid cancers. There are two types of medullary thyroid cancer: sporadic and familial. Approximately 35% of all MTC runs in families and may be associated with other endocrine tumors. Genetic testing (of the RET proto-oncogene) is recommended for those newly diagnosed with MTC. For individuals with a family history, it is helpful to determine whether there are genetic markers present. In individuals with these genetic changes, prophylactic surgery has a high probability of being curative.

• Anaplastic thyroid cancer is difficult to control and treat because it is a very aggressive type of thyroid cancer. Anaplastic thyroid cancer is quite rare, making up less than 2% of patients with thyroid cancer

Risk Factors and Causes of Thyroid Cancer

There are several risk factors that can increase an individual’s chances of developing thyroid cancer, such as a family history of thyroid cancer, gender (women have a higher incidence of thyroid cancer), age (the majority of cases occur in individuals over age 40, although thyroid cancer can affect all ages), and history of ionizing radiation exposure. If you have a family history of thyroid cancer, or other risk factors, speak with your physician about whether thyroid screening and genetic testing may be appropriate for you.

Diagnosing thyroid cancer in its earliest stages can increase the probability of your treatment being more successful. Hoag’s thyroid cancer team is highly skilled in diagnosing and staging thyroid tumors using the latest in state-of-the-art imaging, ultrasound-guide needle biopsy and other specialized tests, including advanced nuclear medicine studies. Upon analysis of test results, Hoag’s multidisciplinary thyroid cancer team develops a personalized treatment plan that addresses all facets of care.

Blood Tests

There are several types of blood tests that may be utilized to diagnose and monitor thyroid cancer patients during and after treatment. Tests for thyroid management include: thyroid hormone levels, thyroid stimulating hormone (TSH) and thyroglobulin. Other blood testing involving molecular markers may also be used, as well as genetic testing for certain types of thyroid cancer.

Imaging Tests

There are several types of imaging studies that may be utilized during diagnosis and to monitor thyroid cancer patients during and after treatment. The most common imaging tests used for diagnosing thyroid cancer include:

• Ultrasound. Ultrasound is an imaging study that uses high-frequency sound waves to create pictures of internal organs. This non-invasive test can help physicians determine the number and size of nodules on the thyroid. It can also help determine whether a nodule is solid, filled with fluid (cyst) or complex (mixed solid and fluid). Ultrasound is an excellent modality for evaluation of the lymph nodes in the neck for possible involvement with thyroid cancer.

• Computerized Tomography (CT). A CT scan is procedure that uses a computer to produce three-dimensional, cross-sectional images of inside the body. CT scans are sometimes ordered for patients with thyroid cancer to examine parts of the neck that cannot be optimally visualized with ultrasound, as well as to determine if the cancer has spread to other areas of the body.

• Magnetic Resonance Imaging (MRI). MRI produces images of the body’s internal structures by passing radio waves through a powerful magnetic field. Differing frequencies of radio waves are produced by the different body structures. In return, these are mapped and converted into digital images by a computer. MRI helps clinicians to distinguish between normal and diseased tissue to identify cancerous cells within the body, and is also useful for exposing metastases. MRI provides greater contrast within soft body tissues as compared to a CT scan.

• Laryngoscopy. Because the thyroid gland is so close in proximity to the vocal cords, thyroid tumors may sometimes affect them. During a laryngoscopy procedure, a thin, flexible scope is guided to the larynx, allowing the physician to examine the throat and larynx for abnormalities, as well as determine how well the vocal cords are functioning.

• Thyroid scan. A thyroid scan is a nuclear medicine imaging study that uses a radioactive iodine tracer to assess the function of the thyroid gland. Typically, this test is only used in cases of hyperthyroidism with the presence of a thyroid nodule. During the test, nodules that produce excess thyroid hormone (called hot nodules) show up on the scan because they absorb more of the iodine tracer. If the nodule absorbs less iodine than the rest of the thyroid gland, then the nodule is called a “cold nodule.” Hot nodules are almost always benign (noncancerous). Although cold nodules have a higher incidence of malignancy than hot nodules, most are benign. Thyroid scans may also be used to detect possible recurrence of previously treated thyroid cancers.

• Positron emission tomography (PET) is a nuclear medicine imaging study that creates detailed, computerized pictures of organs and tissues inside the body. A PET scan is usually combined with a CT scan, called a PET-CT scan. Tumors take up sugar differently than normal tissues do, so a weak radioactive tracer is attached to a sugar molecular and then the PET scan shows area of increased uptake provide images that pinpoint the location of abnormal metabolic activity within the body. For thyroid cancer, this test is a useful alternative to radioiodine scans for patients whose thyroid cancer is not radioactive iodine avid.

Fine Needle Aspiration (FNA) Biopsy

Fine Needle Aspiration (FNA) is the most reliable way to determine whether a nodule is benign or malignant. FNA biopsy is an outpatient procedure in which the area around the nodule is numbed and a thin, hollow needle inserted into the nodule to aspirate (take out) some cells into a syringe. The physician usually repeats this process a few times, taking samples from several areas of the nodule. This procedure is generally done under ultrasound guidance for preciseness and to ensure that enough cells are extracted for evaluation. The extracted cells are then examined under a microscope by pathologists to determine if they are benign or cancerous. In cases where a diagnosis is not clear after an FNA biopsy, cells may be sent for a molecular analysis of the genes in the thyroid nodule. In some equivocal cases, a surgical procedure is needed.

Proper diagnosis is vitally important in determining the best treatment protocol personalized for you. At Hoag, our multidisciplinary thyroid cancer team is highly skilled in the diagnosis and treatment of all types and stages of thyroid cancer.

Patients receive comprehensive and personalized treatment plans that take into account all facets of care. Treatment plans vary, but most often include surgical resection, radioactive iodine treatment, and other targeted therapies specific to the type and stage of cancer for best outcomes.

Surgery

Surgery is the most common initial form of treatment for thyroid cancer and provides excellent outcomes, especially when performed by experienced surgeons who specialize in endocrine surgery.

At Hoag, our highly skilled thyroid surgeons have extensive experience in performing advanced surgical procedures. Most thyroid surgeries can be accomplished using a small incision. Whenever possible, the incision is placed over a natural skin crease to achieve the best cosmetic result.

Your surgeon will discuss the best type of procedure for you, depending on the size and characteristics of your cancer, and whether it has spread to other areas in the body. The most common surgical options include:

• Lobectomy. This surgery removes only the side of the thyroid where the cancerous nodule is located.

• Near-total thyroidectomy. Also called subtotal thyroidectomy, this surgery removes all but a small part of the thyroid gland.

• Total thyroidectomy. This surgery removes the entire thyroid.

In addition, your surgeon may perform a lymph node dissection at the time of surgery to remove all of the lymph nodes in the neck that may contain cancer. The lymph nodes are then biopsied to determine if they contain cancer. This is an important step in helping your physician provide a comprehensive treatment plan.

Preventing Adverse Outcomes

The greatest prevention of injury to your vocal cord or parathyroid glands is an experienced surgeon. Hoag’s surgical team offers a level of expertise that is second to none.

Intraoperative Laryngeal Nerve Monitoring

Surgery on the thyroid gland requires special attention and expertise because of the close proximity of the thyroid gland to the recurrent laryngeal nerve (RLN). Damage to a RLN can cause paralysis of a vocal cord that leads to hoarseness of the voice. At Hoag, intraoperative laryngeal nerve monitoring may be used by surgeons to help them protect the nerves that run close to your thyroid and also to test their functioning during surgery.

Radioactive Iodine Therapy

Radioactive iodine therapy (RAI) has been shown to improve the survival rate of patients with papillary or follicular thyroid cancers that have spread to the neck or other areas, which is why it’s the standard treatment for such cases. Because thyroid cells collect iodine, RAI is an effective tool in specifically targeting radiation to thyroid cells, while leaving other healthy tissue unaffected. During the procedure, the radioactive iodine collects in any thyroid tissue remaining in the body, killing the abnormal cancer cells within the thyroid tissue. Radiation therapy is typically utilized after surgery, and is determined based on a case-by-case basis.

External Beam Radiation

External beam radiation is another type of radiation therapy that uses high-energy X-rays to kill microscopic disease in order to reduce the risk of local recurrence (the cancer returning in the same location). For thyroid cancer, external beam radiation is used only in certain circumstances, such as late-stage thyroid cancer that is unresponsive to radioactive iodine therapy. Hoag Radiation Oncology offers the latest in advanced technologies in this area.

Chemotherapy

Chemotherapy uses specialized medications to kill cancer cells and is sometimes used to treat certain cases of thyroid cancer. Chemotherapy is called a systemic treatment because the medication enters the bloodstream, and travels throughout the body to kill cancer cells.

Targeted Therapy

Targeted therapy is a treatment that targets the cancer’s specific genes, proteins and other factors that contribute to cancer growth and survival. This type of treatment blocks the growth and spread of cancer cells, while limiting damage to the healthy normal cells. Targeted therapies tend to have less severe side effects and are usually better tolerated than – and often tried before – standard chemotherapy. The use of targeted therapy is determined on an individual basis and is most often given as part of a clinical trial.

Hormone Therapy

Patients who are treated with surgery usually require thyroid hormone therapy to replace this important hormone that is essential to the body’s function. For those with papillary and follicular thyroid cancer, the dose of thyroid hormone replacement is usually high enough to suppress one’s own thyroid stimulating hormone (TSH) in order to help prevent the growth of cancer cells, and reduce the risk of one’s thyroid cancer returning.

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