Cushing's disease is a specific type of Cushing's syndrome, a condition caused by prolonged exposure to high levels of the hormone cortisol. In Cushing's disease, the culprit is a non-cancerous tumor in the pituitary gland that produces too much adrenocorticotropic hormone (ACTH). This excess ACTH then signals the adrenal glands to produce excessive cortisol.

The symptoms of Cushing's disease can vary widely, but some of the most common include:

• Weight gain: Often centered around the midsection, face, and upper back.
• Fat redistribution: A rounded face (moon face) and a hump of fat between the shoulders (buffalo hump).
• Muscle weakness: Leading to fatigue and difficulty performing daily activities.
• Thinning skin: Easily bruised skin and poor wound healing.
• Stretch marks: Often purple or pink, especially on the abdomen, thighs, and breasts.
• High blood pressure: Can contribute to heart disease and stroke.
• High blood sugar: Increasing the risk of type 2 diabetes.
• Mood changes: Anxiety, depression, and irritability.
• Osteoporosis: Weakening of the bones, increasing the risk of fractures.

Diagnosing Cushing's disease involves a combination of tests, including:

• Blood tests: To measure cortisol levels and ACTH levels
• Urine tests: To measure cortisol levels
• Salivary cortisol test: To measure cortisol levels at specific times of day
• Imaging tests: Such as MRI or CT scans to identify the pituitary tumor

Treatment for Cushing's disease typically involves surgery to remove the pituitary tumor. In some cases, medication may be used to control cortisol levels before or after surgery. In rare cases, radiation therapy may be necessary.

It's important to note that early diagnosis and treatment of Cushing's disease are crucial to prevent serious complications.