Alzheimer's disease is a progressive neurological disorder that affects the brain, leading to memory loss, confusion, and changes in behavior. It is the most common cause of dementia, a general term for a decline in cognitive abilities severe enough to interfere with daily life.

In Alzheimer's disease, abnormal protein deposits, such as amyloid plaques and tau tangles, build up in the brain, disrupting the communication between nerve cells and ultimately causing their death. This leads to a gradual decline in cognitive functions, including memory, reasoning, and language skills.

The early symptoms often include forgetfulness, difficulty remembering recent events, or repeating questions. As the disease progresses, it can cause more severe symptoms like disorientation, difficulty recognizing loved ones, changes in mood or behavior, and loss of the ability to perform everyday tasks.

Although the exact cause of Alzheimer's isn't fully understood, genetic, environmental, and lifestyle factors are believed to contribute to its development. Currently, there is no cure, but treatments can help manage symptoms or slow the progression of the disease.

• The disease is linked to two abnormal protein buildups in the brain:
  • Amyloid plaques which form between nerve cells and disrupt communication.
  • Tau tangles which develop inside brain cells and block nutrient transport.
    Over time, these changes lead to brain cell death and shrinkage of key memory and reasoning areas.

• Early-Stage Symptoms (Mild)
  • Memory loss that disrupts daily life (especially forgetting recently learned information)
  • Difficulty planning or solving problems
  • Trouble with familiar tasks, such as managing finances or following a recipe
  • Confusion with time or place
  • Misplacing items and being unable to retrace steps
  • Poor judgment or decision-making
  • Changes in mood or personality, such as increased anxiety or depression
  • Withdrawal from work or social activities
• Middle-Stage Symptoms (Moderate)
  • Increased memory loss and confusion
  • Difficulty recognizing friends and family
  • Problems with language, such as finding the right words
  • Sleep disturbances
  • Wandering or getting lost
  • Delusions or suspiciousness
  • Repetitive behavior, like repeating questions
  • Difficulty with personal hygiene and daily care tasks
• Late-Stage Symptoms (Severe)
  • Inability to communicate coherently
  • Loss of physical abilities, such as walking, sitting, or swallowing
  • Need for full-time assistance with daily activities
  • Extreme confusion about past and present
  • Increased vulnerability to infections, like pneumonia

1. Genetics

• Family History: A strong genetic link has been found, especially in cases where multiple family members have had the disease. Certain gene mutations can increase the risk.
• Apolipoprotein E (APOE) gene: A variation of this gene, known as APOE4, has been associated with a higher risk of Alzheimer's. However, having this gene doesn't guarantee the disease, and not everyone with Alzheimer's has the APOE4 variant.

2. Age

• The risk of Alzheimer's increases significantly with age, particularly after the age of 65. However, Alzheimer's can occur in younger people (early-onset Alzheimer's), although it's much rarer.

3. Brain Changes

• Amyloid Plaques: Abnormal clumps of protein called amyloid beta accumulate in the brain, forming plaques. These plaques disrupt communication between brain cells and may trigger inflammation and cell death.
• Tau Tangles: Another protein, tau, forms twisted tangles inside brain cells, which also interfere with cell function and contribute to cell death.

4. Chronic Inflammation

• Inflammation in the brain is thought to play a role in the progression of Alzheimer's disease. The brain’s immune cells may become overactive and cause damage to healthy neurons.

5. Vascular Problems

• Problems with blood vessels, like reduced blood flow to the brain, can contribute to cognitive decline and increase the risk of Alzheimer's. Conditions like hypertension (high blood pressure), diabetes, and high cholesterol can damage blood vessels, increasing risk.

6. Environmental Factors

• Head Injuries: Traumatic brain injuries, especially repeated concussions, can increase the risk of developing Alzheimer's later in life.
• Exposure to Toxins: Long-term exposure to certain environmental toxins or pollutants may also increase risk.

7. Lifestyle Factors

• Diet: A poor diet, particularly one high in fats and sugars, may increase the risk. A Mediterranean diet, rich in fruits, vegetables, and healthy fats, may help lower the risk.
• Physical Activity: Lack of exercise is a risk factor. Regular physical activity is thought to improve brain health and reduce the risk of dementia.
• Social Engagement and Mental Stimulation: A lack of mental and social engagement may contribute to Alzheimer's. Staying mentally active through learning and maintaining social connections may lower the risk.

Neurologists and memory specialists use detailed medical histories, cognitive testing, brain imaging, and lab studies to rule out other causes of dementia and provide an accurate diagnosis. They can also identify patients who may be candidates for new therapies or clinical trials.

1. Medications:

• Cholinesterase Inhibitors: These drugs help increase levels of acetylcholine, a neurotransmitter involved in memory and learning, which is often deficient in Alzheimer’s patients.
  • Donepezil (Aricept)
  • Rivastigmine (Exelon)
  • Galantamine (Razadyne)
• NMDA Antagonists: These medications help regulate the activity of glutamate, a neurotransmitter involved in learning and memory.
  • Memantine (Namenda)
• Combination Therapy: Sometimes, doctors combine Donepezil and Memantine to help with symptoms.
• Anti-Amyloid Antibodies: Newer drugs, like Lecanemab (Leqembi) and Kisunla (Donanemab), aim to target beta-amyloid plaques, which are believed to play a role in the disease’s progression. These medications are still under evaluation, and their effectiveness and safety are debated.
• Antidepressants & Antianxiety Medications: These may be used to address symptoms of depression, anxiety, and agitation, which are common in Alzheimer's patients.