Hoag Family Cancer Institute
16105 Sand Canyon Ave., Ste. 220, Irvine CA 92618
(949) 722-6237
Through innovative clinical research, Hoag physicians explore the efficacy of new drugs, therapies, medical devices and clinical and surgical methods – ensuring you have access to the most advanced treatments available.
Hoag is the top choice for cancer care in Orange County, with cancer survival rates that continually exceed national averages. Our dedicated, world-class teams are wholly focused on helping you survive cancer, heal and move forward with your life.






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Contact usHoag is here for you. The Hoag Melanoma & Skin Cancer Program is a comprehensive path in Orange County for those seeking diagnosis and treatment for melanoma and non-melanoma cancers, such as basal cell, squamous cell and merkel cell cancers. Featuring a world-class roster of specialists in dermatologic oncology, surgical oncology, radiation oncology, hereditary cancer and skin cancer research, Hoag offers the experience and advanced technology you can rely on for high-risk monitoring, diagnosing and treatment of skin cancer.

Vectra WB360 Total Body Photography is available at Hoag – Hoag is the first hospital on the West Coast to offer high-risk skin cancer patients access to the Vectra WB360 as part of its comprehensive Melanoma & Skin Cancer Program. This breakthrough technology allows for whole-body monitoring of suspicious lesions and tracking changes over time.
Hereditary Skin Cancer – For more than a decade, Hoag has been Southern California’s leader in advanced genetic profiling to detect the presence or potential risk of developing certain cancers. Skin cancers that may be hereditary include:
Melanoma
Basal cell carcinoma
Squamous cell carcinoma
If you are concerned about an elevated risk due to a family history of skin cancer, learn more about Hoag’s Hereditary Cancer Program.
Early detection of skin cancer is key to improved outcomes and keeping the cancer from spreading. At Hoag, our skin cancer detection and dermatologic oncology program is second to none when it comes to the accurate, early diagnosis that saves lives. The type of skin cancer is usually determined by where the cancer begins, or which cells are cancerous. Some of these cell types include:
Squamous – found in the upper (outer) part of the epidermis. Squamous cell carcinoma starts in these cells.
Basal – found in the lower part of the epidermis. Basal cell carcinoma starts in these cells.
Melanocytes – these cells make the brown pigment called melanin which gives your skin its tan or brown color. Melanoma skin cancer starts in these cells.
Merkel – found in the top layer of the skin, very close to the nerve endings that receive the sensation of touch. Merkel cell carcinoma usually appears as a single painless lump on areas of the skin exposed to ultraviolet rays and is very rare.
If you visit a physician for a spot, mole, blemish or lump that gives you concern, the doctor will likely examine the spot and the rest of your skin, along with asking you questions about your symptoms and family history. If something concerning is found, a sample from the spot is removed and sent for testing. This is a painless procedure and will likely be done by either:
Punch biopsy
Excision
Our specialized team at Hoag includes a dedicated dermatologist whose only focus is the diagnosis of melanoma and other skin cancers. The benefits of coming to Hoag include:
Shorter waits for exams
In-depth knowledge and expertise
A chance to avoid the “biopsy first” approach
Fewer disfiguring scars and clearer, healthier skin
Access to high-risk management, biopsy, Mohs surgery, other surgical approaches and subspecialty medical oncologists.

If testing shows evidence of melanoma or a non-melanoma skin cancer, it is important to determine whether the cancer has spread, or metastasized, and how extensive it is. This is called staging and may be determined by:
Measuring the thickness of the skin cancer, a thicker melanoma means the disease has penetrated further into the skin and is a more serious case.
If needed, our surgical oncologist can perform a Sentinel Node Biopsy to see if there’s evidence the cancer has spread to nearby lymph nodes.
At Hoag, our expert pathologists specialize in skin cancer & melanoma diagnoses ensuring an accurate skin cancer diagnosis. Precision medicine may also be used to ensure a molecular-based diagnosis. Learn about Hoag’s Precision Medicine Program.

Melanoma and other skin cancers should be handled by experienced, subspecialists who understand the complexity of the cancer and how to best treat it. For patients unsure about their current treatment pathway, Hoag’s Melanoma & Skin Cancer Program offers second opinion consultations. Contact us today for assistance with a second opinion.
Hoag’s Melanoma & Skin Cancer Program has the most complete and comprehensive skin cancer program in Orange County. Our multidisciplinary team has special expertise in providing the most accurate diagnosis and effective treatment plans across all skin cancer types, including performing Mohs surgery. To help patients and their families through diagnosis and treatment to survivorship, our dedicated melanoma and skin cancer clinical nurse navigator acts as facilitator and guide. Learn about our nurse navigator program.Treatment options for skin cancer depend on many factors, such as:
How advanced the cancer is when detected
Your age and any other health issues you may have
Rest assured, Hoag will provide you with world-class expertise and a personalized treatment plan specific to your needs.

The most common treatment for melanoma and non-melanoma skin cancers is surgical removal of that piece of tissue, which usually cures most early-stage lesions. When detected early, Hoag is a leader in performing Mohs Surgery, today’s least invasive surgical option for a full recovery from Melanoma and other skin cancers resulting in better outcomes and less scarring. If you are not a candidate for Mohs surgery, our surgical oncologist offers expertise in non-Mohs surgical interventions, including:
Surgical excision
Sentinel node biopsy
Lymph node dissection
Wide local excision
Through collaboration with Hoag plastic surgeons, patients are able to optimize their appearance and reduce the visibility of scars when needed.
At Hoag, treatment plans for metastasized skin cancers are personalized to meet the needs of each patient. Our treatment options offer the most recent advancements in techniques and technology, including:
Hoag is committed to leading the way in state-of-the-art technologies and advanced treatment options. Part of this commitment includes clinical research with the goal of helping patients live longer, healthier lives. Through carefully planned clinical trials, researchers evaluate the safety and effectiveness of new ways to diagnose, treat and prevent diseases or conditions. Treatments studied in clinical trials might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. View clinical trials for melanoma and other skin cancers here.
Mohs surgery at Hoag offers you an exceptional cure rate with less scarring than traditional skin cancer surgery. Performed by our dedicated dermatologic oncologist, Mohs surgery removes all skin cancer, sparing healthy surrounding tissue. Mohs surgery at Hoag provides:
An experienced team, dedicated solely to skin cancer
A Mohs surgeon with 20+ years of experience
A comfortable, spacious & caring environment
Treatments that are performed on an outpatient basis with local anesthesia.
Call for an appointment.


Mohs surgery is a type of surgery to treat skin cancer. It uses a special technique to remove ALL of the skin cancer but saves healthy tissue in order to limit scarring. Mohs surgery is the most effective treatment for skin cancer. It is often used to treat skin cancer that:
During your surgery, a layer of tissue will be removed from your skin and checked for cancer cells using a microscope. If there are cancer cells, more layers will be removed and checked for cancer cells. This will continue until all the skin cancer has been removed and the margins are clear.
You will not get general anesthesia (medication to make you sleep) during your surgery. You will receive a local anesthetic (medication to make an area of your body numb).
Talk with your health care provider about risks associated with Mohs surgery. Possible risks may include:
You will receive important information about how to prepare for your surgery and have time to review it and ask questions. If you are having a plastic surgeon close your wound, you will get more information.
Your health care provider will review your medications and health history.
If you develop any illness (fever, cold, sore throat or flu) or are hospitalized before your surgery, call your health care provider’s office.
Depending on how many layers of tissue need to be removed, you may be at Hoag for several hours. We recommend that you eat breakfast and bring lunch or snacks with you. We can store your food, if needed.
If you have any questions, call your health care provider’s office.
How Long Does Mohs Surgery Take?
The length of your surgery depends on how many layers of tissue are removed. Be prepared to spend 2-3 hours at Hoag. Again, we recommend that you eat breakfast and bring lunch or snacks with you. We can store your food, if needed.
During Mohs Surgery
First, you will get an injection (shot) of local anesthesia to numb the surgery site. Once the area is numb, the cancerous tissue and a thin layer of surrounding tissue will be removed. A bandage will be placed on your wound.
After your wound is bandaged, you will stay in the procedure room. You can relax and eat light snacks or your lunch while you wait.
A lab will process and examine the removed tissue. If there are cancer cells at the border (edge) of the tissue, they will need to remove another layer of tissue.
These steps will be repeated until they find no more cancer cells at the borders of the tissue.
Closing Your Wound
After all the cancer is removed, you and your doctor will discuss the best way for your wound to close and heal. Examples include:
Before you leave Hoag, you will get instructions about how to care for your wound at home. You will also be told when you need to come back for your follow up appointment.
You will be able to go home right after your procedure.
Hoag is the first hospital on the West Coast to offer high-risk skin cancer patients access to the Vectra WB360 as part of its comprehensive Melanoma & Skin Cancer Program.
The Vectra WB360 is a walk-through machine that has 92 cameras that flash simultaneously to capture a patient’s entire skin surface in less than one second. Powered by an advanced photographic software that uses artificial intelligence, the system generates a 3D avatar of a patient’s entire body and maps out all moles and lesions with high-resolution fidelity.
The system allows dermatologists at the Hoag Dermatologic Oncology program to monitor suspicious lesions and track changes over time, helping dermatologists detect skin cancer at the earliest stage, while avoiding unnecessary skin biopsies.
Hoag patients are now among the first in the nation to have access to the VECTRA WB360’s advanced technology.
"This highly innovative total body photographic imaging system will allow our dermatologists to monitor suspicious lesions and track changes over time." - Stephen Q. Wang, M.D., Director Dermatologic Oncology & Chief of Dermatology

Watch our video to learn more about this groundbreaking technology.

You must first book a consult exam with our oncologic dermatologist, who will determine if you are eligible during the appointment. Depending on your insurance, this consult may be covered by insurance.
The cost of the Vectra total body photographic imaging is $595. Please note that physician fees are billed separately from the Vectra fee.
Currently, most insurance providers in California do not cover this total body photographic imaging or the physician fees associated with the session.
To schedule an appointment, call 949-557-0275.
Be prepared to spend 20 to 30 minutes at your appointment.
Usually less than 5 seconds.
No, these are photos taken with special digital cameras. There is no radiation.
Yes, you may view the photos at the next appointment, either with our oncologic dermatologist or your referring dermatologist.
Most patients will only need to have photos taken by the Vectra WB360 once every 5 to 7 years.

<a href="https://www.hoag.org/featured-physician/steven-q-wang-md">Read More about Dr. Wang</a> Dr. Steven Q. Wang is a board-certified dermatologist and fellowship-trained Mohs micrographic surgeon focusing on the diagnosis, treatment and prevention of melanoma, squamous cell cancer, basal cell cancer and other skin cancers. Dr. Wang deploys technologies to detect melanoma and other skin cancers at early stages while avoiding unnecessary skin biopsies. He uses noninvasive treatment approaches and is capable of performing Mohs micrographic surgery and reconstruction to minimize scarring. Currently, Dr. Wang serves as the Medical Director of Dermatologic Oncology at Hoag Family Cancer Institute. His clinical practice is focused only on the prevention, diagnosis, and treatment of skin cancers. Dr. Wang understands the emotional and psychological stresses faced by patients and their family members. He strives to deliver compassionate and personalized care to every patient with a holistic approach while addressing their physical ailments and, more importantly, alleviating their emotional stress and psychological challenges associated with skin cancer. In addition to caring for patients, Dr. Wang is actively involved in clinical and basic research with a focus on melanoma detection, photoprotection and application of artificial intelligence in skin cancer detection. Dr. Wang has published more than 100 articles in peer-reviewed scientific journals and academic textbooks, written five books and has lectured throughout the world on the topics of skin cancer detection, treatment and prevention. Dr. Wang joined Hoag after spending 16 years at Memorial Sloan Kettering Cancer Center, where he served as the Head of Dermatology Section and Director of Dermatologic Surgery and Dermatology. He also served as associate professor at Weill Medical College of Cornell University in New York City during this period. Dr. Wang is the co-founder of the Nanodermatology Society and serves as the president of the Photodermatology Society and chair of the Photobiology Committee of the Skin Cancer Foundation. He has appeared on a number of television and radio programs and has been interviewed the Wall Street Journal, New York Times and Reuters. <style> .hoag-people__bio-content p a { display: inline-block; padding: 15px 30px; background-color:#f16c13; color: #fff; text-decoration: none; border-radius: 50px; font-weight: bold; transition: background-color 0.3s ease; } .hoag-people__bio-content p a:hover { color: #fff; background-color: #f68d2a; } </style>

Thomas Wang, M.D., Ph.D., is a board-certified surgical oncologist with the Hoag Family Cancer Institute and the medical director of the Hoag Melanoma/Advanced Skin Cancer Program. Dr. Wang comes to Hoag after spending the previous 15 years at the University of Alabama at Birmingham (UAB), where he served as a Professor of Surgery at the UAB School of Medicine and Chief of Surgical Oncology for the Birmingham VA Medical Center. He is a recognized author and researcher and has published over 40 original manuscripts in peer- reviewed scientific journals and ten book chapters. He has presented his clinical and basic science research at multiple national and international meetings. Dr. Wang is a graduate of Brown University and attended the Lewis Katz School of Medicine at Temple University. He completed his general surgery residency training at Drexel University College of Medicine/Hahnemann University Hospital and his surgical oncology fellowship at the University of Texas M.D. Anderson Cancer Center. Dr. Wang’s clinical interests include melanoma, soft tissue sarcomas and endocrine surgery. Dr. Wang is an active member on multiple national surgical societies, including the Association for Academic Surgery, the Society of University Surgeons, the American Association of Endocrine Surgeons and the Society of Surgical Oncology. In addition, since 2007, he is a panel member in the National Comprehensive Cancer Network, developing guidelines for the treatment of thyroid cancer.

Oncology/Hematology

<div> <p dir="ltr"><span>Simon Khagi, MD, is Medical Director of Neuro-Oncology at Hoag Family Cancer Institute and a board certified medical and neurological oncologist. Dr. Khagi’s areas of expertise include treating primary brain and spine cancers, as well as lung cancers and advanced skincancers. His areas of expertise include: immunotherapy, genomically-guided therapy, oncolytic virotherapy, adoptive cell therapy (i.e. NK and chimeric antigen receptor T cells), and alternating tumor treating fields. He has significant experience with glioblastoma, astrocytoma, oligodendroglioma, meningioma, ependymoma, medulloblastoma, germ cell tumors, brain metastases, rare brain tumors, lung cancers, melanoma, and other advanced skin cancers.</span></p> <p dir="ltr"></p> <p dir="ltr"><span>Dr. Khagi has always felt a strong connection with patients and families battling cancer. His desire to help them motivated him to become an oncologist. According to Dr. Khagi, he considers quality and quantity of life as two sides of the same coin when supporting his patients. Valuing both is a cornerstone of the care he provides.</span></p> <p><span> </span></p> <p dir="ltr"><span>Previously, Dr. Khagi was an Assistant Professor of Medicine at the Geisel School of Medicine at Dartmouth. He also served as an Associate Oncology Service Line Director and Regional Medical Director at Dartmouth Cancer Center. Prior to joining Dartmouth, Dr. Khagi served as the Director of the Neuro-Oncology and Brain Metastases Program at the University of North Carolina at Chapel Hill UNC.</span></p> <p><span> </span></p> <p dir="ltr"><span>Dr. Khagi is active in clinical research, having conducted numerous clinical trials focusing on glioblastoma, meningioma, advanced glioma, and brain metastases, among others. While at UNC, he led many novel research protocols, including the first institutional use of a live virus delivered directly into the brain against brain tumors, in addition to contributing to the development of a novel CAR T cell technology for glioblastoma. To date, Dr. Khagi has authored or co-authored over fifty book chapters, peer-reviewed manuscripts and abstracts. Selected list of publications.</span></p> <p><span> </span></p> <p dir="ltr"><span>Having received multiple honors throughout his career and being inducted as a fellow of the American College of Physicians, Dr. Khagi has also received the “Healthcare Hero Award” from the Head for the Cure Foundation and the “Exemplary Service Award” from the UNC Division of Medical Oncology along with multiple research grants.</span></p> <p><span> </span></p> <p dir="ltr"><span>Dr. Khagi feels strongly about raising awareness of the societal burden of cancer and speaks regularly at community outreach events, in addition to sitting on multiple advisory boards focused on improving cancer care.</span></p> <p dir="ltr"></p> <p dir="ltr"><span>Dr. Khagi has always felt a strong connection with patients and families battling cancer. The desire to help them motivated him to become an oncologist. According to Dr. Khagi, he considers quality and quantity of life as two sides of the same coin when supporting his patients. Valuing both is a cornerstone of the care he provides. </span></p> <p dir="ltr"></p> <p dir="ltr"><span>Previously, Dr. Khagi was an Assistant Professor of Medicine at the Geisel School of Medicine at Dartmouth. He also served as an Associate Oncology Service Line Director and Regional Medical Director at Dartmouth Cancer Center. Prior to joining Dartmouth, Dr. Khagi served as the Director of the Neuro-Oncology and Brain Metastases Program at the University of North Carolina at Chapel Hill UNC. </span></p> <p dir="ltr"></p> <p dir="ltr"><span>Dr. Khagi is active in clinical research, having conducted numerous clinical trials focusing on glioblastoma, meningioma, advanced glioma, and brain metastases, among others. While at UNC, he led many novel research protocols, including the first institutional use of a live virus delivered directly into the brain against brain tumors, in addition to contributing to the development of a novel CAR T cell technology for glioblastoma. To date, Dr. Khagi has authored or co-authored over fifty book chapters, peer-reviewed manuscripts and abstracts. Selected list of publications.</span></p> <p dir="ltr"></p> <p dir="ltr"><span>Having received multiple honors throughout his career and being inducted as a fellow of the American College of Physicians, Dr. Khagi has also received the “Healthcare Hero Award” from the Head for the Cure Foundation and the “Exemplary Service Award” from the UNC Division of Medical Oncology along with multiple research grants. </span></p> <p dir="ltr"></p> <p dir="ltr"><span>Dr. Khagi feels strongly about raising awareness of the societal burden of cancer and speaks regularly at community outreach events, in addition to sitting on multiple organizational boards focused on improving cancer care.</span></p> </div>
Hoag’s Precision Medicine Program combines genomics and genetics to diagnose, treat, and prevent diseases. Using the latest advances in genomic technologies, targeted therapies and research, our precision medicine program brings together a multidisciplinary team, including a robust genetic counseling group of experts, to provide patients with the latest in innovation and technology.
Hoag Family Cancer Institute provides a dedicated team of genetic counselors that offer hereditary cancer assessment, offering risk assessment and genetic cancer testing to those with a personal or family history of cancer.
Being diagnosed with cancer can feel overwhelming at times. Many patients and their families need help with coping and can benefit from supportive counseling. Oncology Clinical Social Workers are available to provide emotional and practical support during all stages of cancer including diagnosis, treatment and post-treatment survivorship.
Hoag Family Cancer Institute dietitians work closely with patients’ physicians, nurses, therapists, and social workers to ensure complete care.
Melanoma is a type of skin cancer that originates in the melanocytes, the cells that produce pigment in the skin. Melanomas can develop anywhere there is pigmented skin, even on internal organs or the eyes, but most often occur on parts of the body exposed to the sun, including the face, arms, back and legs.Though melanoma is very treatable if diagnosed early, it is considered the most dangerous type of skin cancer due to its quick growth and ability to spread to any organ inside the body. Though only about 1 percent of all diagnosed skin cancers in the U.S. are melanoma, the disease causes the majority of skin-cancer-related deaths.
At Hoag, Our Whole-Body, Patient-First Philosophy Is All About You
Helping to limit anxiety and calm fears, when patients come to us with a potentially worrisome blemish, spot or mole, our skin exams are detailed and thorough, helping patients feel confident and comfortable. Our team sees every exam as an opportunity to educate and our world-class team of specialists take the time to explain as we examine, helping patients not only understand why one mole is safe while another is potentially malignant, but also which specific factors lead to that determination.
At Hoag, we understand the power of seeing every patient as a whole person, not just a name on a chart. And it’s another great reason to trust Hoag for your dermatologic care.
The most frequent early symptom of melanoma is finding a previously-unnoticed spot on the skin, or changes to the size, shape or color of an existing mole or blemish.
In evaluating suspect spots, moles or blemishes, the CDC suggests that those deciding whether to consult their doctor should remember “A-B-C-D-E.” It stands for:
If the answer to one or more of these questions is yes, be safe and see your doctor.
There are a number of factors that are believed to increase your risk of developing melanoma.
Certain individuals are at higher risk for melanoma. These may include:
However, not all melanomas are at high risk. Here are some additional, more specific, risk factors for melanoma:
Ways to reduce your risk of developing melanoma may include:
The simplest step is to visit your dermatologist for a skin check-up once a year, or every six months if you have a family history.